Medical Marijuana - Parkinson's Foundation in Pomona-California

Published Nov 24, 22
5 min read

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Levodopa is the most effective and most commonly used treatment for PD. This medication helps replenish the level of dopamine in the brain. Levodopa addresses many of the motor symptoms of Parkinson’s disease. That includes tremors or muscle stiffness. However, this medicine does little to tackle the nonmotor symptoms of Parkinson’s disease.

They include anxiety, depression, and sleep quality. What’s more, prolonged use of levodopa may cause side effects like agitation, anxiety, confusion, and nausea. It may also cause a type of tremor that’s the result of the medication itself, not PD.CBD appears to be best suited to address those nonmotor issues and potential side effects, rather than motor issues.

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However, this study included THC with CBD, not CBD alone. CBD holds some promise for people with Parkinson’s disease. Not only might the cannabinoid ease symptoms of the degenerative disease itself, it might ease side effects of the most common treatment. But it’s important to remember that many of these studies are quite small.

Yet, the results have been promising, so there’s reason to be optimistic for future research. Some doctors are becoming more open to CBD as a complementary treatment, so talk to your doctor about what you’re experiencing and how to get relief using CBD or other methods. The 2018 Farm Bill removed hemp from the legal definition of marijuana in the Controlled Substances Act.

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3 percent THC federally legal. However, CBD products containing more than 0. 3 percent THC still fall under the legal definition of marijuana, making them federally illegal but legal under some state laws. Be sure to check state laws, especially when traveling. Also, keep in mind that the FDA has not approved nonprescription CBD products, and some products may be inaccurately labeled..

A number of small studies and anecdotal evidence suggests that cannabidiol (CBD) oil for Parkinson’s may help with some symptoms. However, there is no conclusive research showing CBDs effectiveness in treating Parkinson’s or its symptoms.The Parkinson’s Foundation issued a Consensus Statement on the Use of Medical Cannabis for Parkinson’s Disease in 2020.

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The statement urges caution, pointing to potential side effects, and emphasizes the need for more research. That said, as of yet, the Food and Drug Administration has only approved one CBD-based drug for the treatment of a rare seizure disorder. This approval has increased interest in the use of CBD in the treatment of movement disorders, such as Parkinson’s.

A number of studies suggest that there may be some benefits of CBD for Parkinson’s. The problem is that most of these studies are small, low quality, or animal studies rather than human ones. Additionally, because the FDA does not regulate CBD products, there is no guarantee that product purity is consistent, making it difficult to get the right dose.

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More research needs to test this claim. A 2020 study tested Epidiolex, an FDA-approved CBD drug for seizures, for Parkinson’s. Of 13 participants, three quit the study because of side effects. The remaining 10 experienced improvements in their Parkinson’s disease symptoms. However, five of 13 participants developed elevated liver enzymes — a side effect the researchers attribute to the high dose of the drug.

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A 2019 paper reviewed prior studies on CBD and Parkinson’s. The study included four randomized controlled trials. However, just one of these trials showed improvements in Parkinson’s symptoms among participants. In seven preclinical models of Parkinson’s disease, six studies suggested CBD could offer neuroprotective benefits. In three additional trials of CBD and Parkinson’s — one randomized controlled trial, one case series, and one open-label study — participants tolerated CBD well.

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Non-motor symptoms can be more difficult to treat with standard Parkinson’s treatment. Once again, however, these studies involved only small groups of participants and were short in length. The 2018 Farm Bill removed hemp from the legal definition of marijuana in the Controlled Substances Act. This made some hemp-derived CBD products with less than 0.

However, CBD products containing more than 0. 3 percent THC still fall under the legal definition of marijuana, making them federally illegal but legal under some state laws. Be sure to check state laws, especially when traveling. Also, keep in mind that the FDA has not approved nonprescription CBD products, and some products may be inaccurately labeled.

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Studies of CBD often use dosages of per day. People who want to try CBD should start with a low dosage, then gradually increase the dosage only if they experience no side effects. Before trying CBD, contact a doctor about the risks and benefits, as well as any potential drug interactions.